Genetic Bone Associated Problems

A study revealed that some genetic variants lead to fracture risk in a person and also affects the bone density. This study can help in analyzing new ways through which bone fracture and loss can be prevented. There are around 9 million people around the world affected by Osteoporosis. Genetics is considered to be the primary reason behind it. With age the bone density tends to decrease and poses a major risk for fracture. There are many genetic factors associated with Osteoporosis.

Scientists have been trying since many years to link genetic variants with diseases and traits. Their studies have uncovered many small effects that largely contribute to a bone disorder. In fact some small factors lead to big issues in course of time. An international team of doctors in the UK conducted a study on the role of rare genetic factors in fracture risk. A massive project in which whole genome sequence were obtained. Genome sequencing test were conducted on more than 2800 people. Scientists also gathered the sequence of exomes of more than 3500 people. Then the data was compared from the results from previous studies.

The association between the bone mineral density and genetic variants was hence determined. The results were shocking in many aspects. people never imagined of the possibilities. The team used a mouse model and altered their En1 level which later proved that it plays a major role in bone density level. Study continues to find more possibilities in this field, in 2016 new things might get revealed.

Surprising Effects of Allergy Drugs

A study showed that over the counter allergy drugs reduced the level of hepatitis C virus in affected mice. A drug named chlorcyclizine HCL (CCZ) is presently being tested in chronic patients with hepatitis C. You should be knowing that in Hepatitis C a virus attacks the liver of affected person. People who get affected by Hepatitis C virus develop about 80 % infection in their body. Their body become incapable of getting rid f the virus and the illness becomes chronic. If left untreated it can lead to liver cancer and several other liver problems.

It is estimated that around 185 million people all around the world are affected by chronic Hepatitis C. Today also there is no vaccine to prevent this infection. However, treatments are available for this chronic illness. The only demerit is that the treatment is very expensive. A single medicine can cost thousands of dollars. Scientists are trying to develop a way to find out affordable and effective treatment methods, but no success has been achieved in this field. The researches helped identify multiple allergy relieving antihistamines that also help with antiviral activity.

The drug also inhibited the HCV infection caused in human liver cells. Mice implanted with human liver cells also showed inhibition of HCV infection. That mouse was treated for about 5 to 6 weeks and the virus level was significantly reduced. Steps are taken further to develop an effective method and drug. A vaccine would be best, but no clues are available yet.

Nerve Pathways Repaired By 3D Printing

Recently 3D printing was used to treat damaged rat nerves. It helped produce custom scaffolds which helped the rat improve his walking ability. This study has put some light on the process of making customized scaffolds some day for tissue regeneration. Peripheral nerves are those that spread from our brain and spinal cord to the rest of the body. Damage can be caused to them in various ways. Traumatic injuries, some kind of disease or many other reasons can lead to their damage. Depending on the specific type of injury, treatments are available today for it.

Nerve development is not that simple as it sounds. Many chemical and physical prospects need to be taken in to consideration while developing nerves. Presently the treatment involved taking a certain part of healthy tissue from another part of the body and using it in the place of affected nerve. Harvesting surgery, that is graft is a way limited by size and geometry of nerve. This procedure can lead to several other problems in the host place. Problems can include sensory loss, chronic pain, harmful immune response, etc

A team studying this procedure conducted an experiment on rats. They used 3D light scanning method to prepare a cast of nerves. The conventional imaging technology used can prove to be very helpful in future. Still nothing is sure enough and is not employed on humans yet. With time this process can be checked on humans.